Astor was last spotted smoking a cigar on the deck. His body was later pulled out of the sea. His wife gave birth to a son weeks later.
"I think he stayed to the very end, putting people in lifeboats," said Drexel, his granddaughter. "He never tried to escape himself."
Drexel believes he would have been pleased with the way his legacy has been preserved at the St. Regis. If he had survived the sinking, she believes he would have built many more hotels in his lifetime.
"It makes me proud to speak of him," she said. "I wish I'd known him. I wish my dad had known him. I think that's the saddest - that dad never had a chance to meet him."
Image: The Titanic at the docks of Southampton prior to its fateful departure.