Priscilla Chan and Zuckerberg live together in the modest house in Palo Alto, California, where they were married on Saturday.
The couple met as undergraduates at Harvard University in 2004.
Zuckerberg, now 28, dropped out of college to work on Facebook, while Chan, a pediatrician, stayed to earn her undergraduage degree in 2007.
Chan's work led to Facebook created an organ donation page.
The pair recently travelled to China.
Image: Zuckerberg (R) and Chan, then his girlfriend, walk near Fuxing Road in Shanghai in this March 27, 2012 file photo.