Regina made her debut with Kanda Naal Muthal, and did the lead role in Azhagiya Asura which which was a dud. Later, the actress did a couple of Telugu films and tried her luck in Tollywood before she scored her first hit in Tamil with Sivakarthikeyans Kedi Billa Killadi Ranga. She had a small role in Rajathandhiram which did decent business at the box office but no big offers came her way. Maanagaram once again brought Regina back to the limelight but after that almost all her films bombed at the box office. In 2017, Regina's Saravanan Irukka Bayamaen and Gemini Ganesanum Surulirajanum were disasters.
Last year, Mr. Chandramouli was one of the biggest disasters in Tamil cinema (remember she went bold in a bikini and some hot scenes for a song in the film which backfired). Now her X'mas release Silukkuvarpatti Singam also didn't shine at the box office.
The actress has another ambitious film Nenjam Marapathillai which is lying in the cans for more than two years and no one is sure about the release. She is also a part of the multi-starrer Party. In Telugu too, Regina Cassandra hasn't given a hit. It is nothing but bad luck which could have been the reason why she never really reached where she should have. Hope lady luck smiles on the pretty actress soon!