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Mussels inspire new alternative adhesive for surgery

Source : ANI
Last Updated: Thu, Jan 10, 2013 09:50 hrs

The chemistry that lets mussels stick to underwater surfaces may provide a highly adhesive wound closure and more effective healing from surgery.

In recent decades bioahesives, tissue sealants and hemostatic agents became the favored products to control bleeding and promote tissue healing after surgery.

However, many of them have side effects or other problems, including an inability to perform well on wet tissue.

"To solve this medical problem, we looked at nature," Jian Yang, associate professor of bioengineering at Penn State said.

"There are sea creatures, like the mussel, that can stick on rocks and on ships in the ocean. They can hold on tightly without getting flushed away by the waves because the mussel can make a very powerful adhesive protein. We looked at the chemical structure of that kind of adhesive protein," Yang said.

Yang, along with University of Texas-Arlington researchers Mohammadreza Mehdizadeh, Hong Weng, Dipendra Gyawali and Liping Tang, took the biological information and developed a wholly synthetic family of adhesives.

They incorporated the chemical structure from the mussel's adhesive protein into the design of an injectable synthetic polymer.

The bioahesives, called iCMBAs, adhere well in wet environments, have controlled degradability, improved biocompatibility and lower manufacturing costs, putting them a step above current products such as fibrin glue and cyanoacrylate adhesives.

The researchers tested the newly developed iCMBAs on rats, using the adhesive and finger clamping to close three wounds for two minutes. Three other wounds were closed using sutures.

The iCMBAs provided 2.5 to 8.0 times stronger adhesion in wet tissue conditions compared to fibrin glue.

They also stopped bleeding instantly, facilitated wound healing, closed wounds without the use of sutures and offered controllable degradation.

The iCMBAs are also non-toxic, and because they are fully synthetic, they are unlikely to cause allergic reactions. Side effects were limited to mild inflammation.

The iCMBAs could eventually be used in a wide range of surgical disciplines from suture and staple replacement to tissue grafts to treat hernias, ulcers and burns.

The findings are published in the journal Biomaterials. (ANI)




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