Barring minor incidents, the shutdown remained peaceful in the region, which comprises 10 districts including Telangana.
Transport services in Hyderabad and nine other districts of the Telangana region were paralysed while shops, business establishments and educational institutions remained closed.
Buses of state-owned Road Transport Corporation (RTC) could not come out of the depots since early Tuesday as the RTC employees too joined the strike in many places.
The shutdown called by the Telangana Joint Action Committee (JAC) evoked a near total response in almost all the towns across the region as people voluntarily shut down businesses and joined the protests.
Image: Youngsters play cricket at the Mahatma Gandhi bus station during a 48-hour strike called by Telangana supporters in Hyderabad on Tuesday, Feb 22, 2011. (Photographs copyright PTI)