Unemployment, multiple job losses and short periods without work may be associated with an increased risk for acute myocardial infarction, researchers say.
Matthew E. Dupre and his colleagues from Duke University, Durham, N.C., examined the associations between different dimensions of unemployment and the risks for AMI in 13,451 U.S. adults aged 51 to 75 years in the Health and Retirement Study with biennial follow-up interviews from 1992 to 2010.
"Results demonstrated that several features of one's past and present employment increased risks for a cardiovascular event. Although the risks for AMI were most significant in the first year after job loss, unemployment status, cumulative number of job losses and cumulative time unemployed were each independently associated with increased risk for AMI," the authors wrote.
The study group (median age 62 years) had 1,061 AMI events (7.9 percent) during 165,169 person-years of observation. In the study group, 14 percent of the individuals were unemployed at baseline, 69.7 percent had one or more cumulative job losses, and 35.1 percent had spent time unemployed, according to the study.
Statistical analysis indicated that AMI risks were significantly higher among the unemployed (hazard ratio [HR], 1.35) and that risks increased incrementally from one job loss (HR, 1.22) to four or more cumulative job losses (HR, 1.63) compared with no job loss.
The risks for AMI also were "particularly elevated" within the first year of unemployment (HR, 1.27) but not thereafter, according to the results.
"We found that the elevated risks associated with multiple job losses were of the magnitude of other traditional risk factors, such as smoking, diabetes mellitus and hypertension," the authors said.
"In the context of the current U.S. economy and projected increases in job instability and unemployment among workers, additional studies should investigate the mechanisms contributing to work-related disparities in AMI to identify viable targets for successful interventions," they added.
The study has been published online by Archives of Internal Medicine. (ANI)