Aging gene could help alter immunity in humans

Last Updated: Sat, Apr 03, 2010 10:40 hrs

Scientists have discovered that study of a gene called DAF-16 which is found in many animals, including humans, could open up new avenues for altering ageing, immunity and resistance in humans.

DAF-16 is strongly involved in determining the rate of ageing and average lifespan of the lab worm C. elegans and its close evolutionary cousins.

Robin May, University of Birmingham, who led the research said: 'Ageing is a process that all organisms experience, but at very different rates. We know that, even between closely related species, average lifespans can vary enormously.'

'We wanted to find out how normal ageing is being governed by genes and what effect these genes have on other traits, such as immunity,' said May.

'We looked at a gene that we already knew to be involved in the ageing process, called DAF-16, to see how it may determine the different rates of ageing in different species,' said May.

May and colleagues compared longevity, stress resistance and immunity in four related species of worm. They also looked for differences in the activity of DAF-16 in each of the four species and found that they were all quite distinct in this respect.

And, importantly, the differences in DAF-16 corresponded to differences in longevity, stress resistance and immunity between the four species-in general higher levels of DAF-16 activity correlated with longer life, increased stress resistance and better immunity against some infections.

May continued: 'DAF-16 is part of a group of genes that drive the biological processes involved in ageing, immunity and responses to physical or environmental stresses.'

'The fact that subtle differences in DAF-16 between species seem to have such an impact on ageing and health is very interesting and may explain how differences in lifespan and related traits have arisen during evolution,' added May, according to a Birmingham release.

The research in Birmingham is now moving on to look at the way in which DAF-16 coordinates a complex network of genes in order to balance the differing needs of an individual's immune system over time.

The research was published the April issue of PLoS ONE.

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