Defending champions Liezel Huber and Lisa Raymond were upset in the third round of women's doubles at the U.S. Open on Sunday.
The top-seeded team lost 6-4, 2-6, 6-4 to Hsieh Su-wei and Anabel Medina Garrigues.
Brothers Christian and Ryan Harrison of the U.S., making their Grand Slam debut together, advanced to the quarterfinals in men's doubles as wild cards. Christian, 18, and Ryan, 20, beat 14th-seeded Brits Colin Fleming and Ross Hutchins 6-3, 6-4.
Defending mixed doubles champs Melanie Oudin and Jack Sock lost in the second round. Sania Mirza and Colin Fleming beat the young Americans 6-4, 7-6 (7).
American teen Sloane Stephens, who lost in the third round to Ana Ivanovic in singles Saturday night, pulled out of her mixed doubles match with Rajeev Ram because of a left abdominal strain. The top-seeded team of Huber and Max Mirnyi advanced with the walkover.
Andrea Hlavackova, who faces Serena Williams in Monday's fourth round and injured her right hip flexor Saturday, played her women's doubles match Sunday but pulled out of mixed doubles. Hlavackova and Lucie Hradecka, the 2011 French Open champs, won their match in straight sets.