Kaleena Mosqueda-Lewis scored 24 points and Bria Hartley added 20 to lead No. 3 Connecticut to a 94-37 rout of Marquette on Tuesday night.
Mosqueda-Lewis hit her first eight shots and her first five 3-point attempts, while Hartley tied a career high with five 3-pointers.
Six Huskies scored in double figures, including all five starters. Caroline Doty added 12 points, going 4-of-4 from behind the arc for the Huskies (21-1, 8-1 Big East), who were coming off a lackluster six-point win at St. John's.
Brookly Pumroy had 11 points to lead Marquette (11-11, 3-6), which has never beaten UConn in nine attempts.
Marquette opened the game with a 3-point basket from Chelsie Butler, but that was the only lead the Golden Eagles would enjoy.
UConn responded with a 19-0 run, capped by Doty's third 3-pointer of the game. A pair of free throws from Kelly Faris gave the Huskies their first 30-point lead at 38-8 midway through the first half and the rout was on.
Coach Geno Auriemma had criticized Mosqueda-Lewis recently for not looking for her shot as much as she should. She responded by hitting all seven of her attempts in the first half Tuesday, including five from behind the arc. Mosqueda-Lewis now leads the nation with 67 3-pointers. She came into the game ranked second in accuracy from behind the arc hitting just under 50 percent of her attempts.
Marquette, meanwhile, made just six baskets as a team in the first half, shooting 20 percent from the floor. They went into the locker room trailing 62-17 at halftime.
UConn did not let up much in the second half, leading by as many as 58 points. The Huskies were 15 of 23 from 3-point range and shot 55 percent from the floor.
Hartley, who was 0 for 7 from 3-point range Saturday, hit 5-of-7 against the Golden Eagles.
Stefanie Dolson returned to the lineup after missing the St. John's game with a stomach bug and chipped in with 15 points. With the junior center on the bench, the Red Storm matched the Huskies, scoring 26 points in the paint. UConn had 30 inside points Tuesday, to just 14 for Marquette.
Katherine Plouffe, Marquette's leading scorer, was held to just four points. She didn't score in the teams' first meeting this season, an 85-51 UConn win on Jan. 12.
The game was the first in a three-game road trip for Marquette, which heads to Villanova and Cincinnati before going home to host No. 2 Notre Dame on Feb. 17.
UConn played without backup point guard Brianna Banks, who will miss the remainder of the season with a torn anterior cruciate ligament in her right leg.
Banks suffered the injury during the first half of the Huskies' 71-65 victory over St. John's on Saturday. The school released the diagnosis on Monday and said surgery would be scheduled in the coming weeks. The sophomore from Newnan, Ga. had been averaging 7.3 points and 1.7 assists in just over 17 minutes per game. She was shooting 47.9 percent from the field.