Kaleena Mosqueda-Lewis scored a season-high 25 points and No. 2 Connecticut pulled away in the second half to beat No. 10 Penn State 67-52 on Thursday night.
Brianna Banks added 10 points for the Huskies (8-0), who won their fourth game this season against a ranked opponent and their second this week against a top 10 team. The Huskies beat No. 9 Maryland 63-48 on Monday.
Maggie Lucas scored 15 points and Ariel Edwards added 10 for Penn State (6-2), which trailed by just six points at halftime and by three early in the second half.
Mosqueda-Lewis started the game despite a left thigh bruise that kept her out of more than half of the win over Maryland. She hit four of her seven shots from 3-point range and added five rebounds.
Penn State got as close as 32-29 on a layup by Talia East with 16 minutes left. But a floater by Banks gave UConn an eight-point lead and she made it 40-31 with another short jumper with 12:25 to go.
Connecticut turned on the defensive pressure, getting three steals in a little more than a minute that turned into three layups, two by freshman Moriah Jefferson, and a 51-36 lead.
It was 53-41 before a 9-0 Huskies run that put the game away.
Penn State had a lead twice in the first half. The first came when Lucas scored five straight points to make it 16-14.
Until that point, UConn had trailed for just 17 seconds this season.
The Huskies were down 18-16 before closing the half on a 12-4 run over the last 9:21 to lead 28-22 at the break.
UConn, which came in averaging just more than 7.5 turnovers a game, had 10 at halftime and just eight field goals.
Mosqueda-Lewis scored seven of the Huskies' first 10 points. The sophomore missed the previous game against Colgate after sustaining a concussion against Purdue on Nov. 24.
Connecticut coach Geno Auriemma picked up his first technical foul of the season 33 seconds into the second half after Stefanie Dolson was hit with a touch foul while trapping on defense. The teams combined for 38 fouls, 16 on UConn and 22 on Penn State. But Lucas was the only player to foul out.
The Huskies have beaten their ranked opponents by an average of 24 points. UConn is 187-58 against ranked teams and 85-41 against top 10 opponents
Penn State's only other loss came a week ago to Miami when the Lions turned the ball over 29 times. They had 26 turnovers in this one, but forced 20 by UConn.
UConn has won eight straight against Penn State, including a 77-59 victory in last season's NCAA regional semifinals in Rhode Island.
This was the first time that the Lions have been in a battle of top 10 teams since losing to UConn in the 2004 NCAA regional finals.
Connecticut will travel to Penn State next season as part of the home-and-home series.