Elizabeth Williams had 20 points and 13 rebounds to help No. 5 Duke beat No. 19 Florida State 61-50 on Friday night.
Chloe Wells added 15 points for the Blue Devils (25-1, 15-0 Atlantic Coast Conference), who won their 37th consecutive home game against ACC competition.
Duke trailed 24-20 early in the second half but seized control with a 26-4 run over the next 9 minutes.
Wells hit a jumper from the free throw line to give the Blue Devils a 28-26 lead with 15:36 remaining, and they never trailed again.
Wells added a pair of 3-pointers, the second of which gave her team a 43-28 cushion with 9 minutes left.
Alexa Deluzio scored 16 points to lead Florida State (20-6, 10-5), which lost its sixth straight matchup with Duke. Natasha Howard added 15 points and 11 rebounds for the Seminoles.