Jewell Loyd had 22 points and nine rebounds and No. 6 Notre Dame dominated the boards in an 81-62 victory over No. 19 Michigan State on Monday night.
Taya Reimer added 19 points and 13 rebounds for the Irish (2-0), who finished with a 52-29 rebound advantage.
Becca Mills scored 15 points for the Spartans (0-1).
The last two meetings between Notre Dame and Michigan State — in 2008 and 2009 — were won by the Fighting Irish by a total of seven points.
Notre Dame improved to 28-5 overall — and 9-1 at home — against ranked teams over the past two seasons.
The Irish have won 15 of their last 16 games in November, with the only loss coming to No. 1 Baylor in 2011.