Shoni Schimmel had 16 points to lead No. 9 Louisville past Portland 95-48 on Sunday.
Bria Smith scored 15, Sheronne Vails had 13 and freshman Megan Deines added 12. Shawnta' Dyer scored 10 for Louisville (2-0).
Kari Luttinen and Ellen Nurmi each had 10 points for the Pilots (0-2).
Louisville opened the game on a 17-2 run and never trailed. The Cardinals forced 19 first-half turnovers, including 12 steals, out of their full court zone press and held the Pilots to just nine field goals. Portland turned the ball over 32 times in all.
Deines' putback at the buzzer gave Louisville a 48-25 halftime advantage.
Louisville had an 11-4 run after halftime, capped by Deines' three from the left corner to give the Cardinals a 59-30 edge.
Louisville had 11 players score, 10 in the first half. Freshman Cortnee Walton's steal and layup put her in the scoring column with 3:32 remaining and gave Louisville an 88-44 lead.
"I'd love to have games like this to be able to use that many players, but that's not realistic," Louisville coach Jeff Walz said. "Sometimes we may just use seven or eight players."
It was a much different offensive outing for Louisville than Friday night's opener against No. 15 Texas A&M.
The Cardinals spurted to a 10-point halftime lead against the Aggies but were stifled by A&M's size in the second half. Louisville rallied though and won 47-45.
"That first game was just a grind," Walz said. "I wasn't sure if we could score 50 points all season. We're going to have games where we grind it out 47-45 and then we'll have some games like today."
The matchup against Texas A&M served Louisville well when the Pilots shifted defenses.
"It was a different game for everybody in that it was an easier game to get things going," Schimmel said. "They sat in zone for the most part but when they went to man, it was easier to run different plays from our offense. What helped us was playing against man against Texas A&M."
Louisville had 23 turnovers in the opener but committed just 13 against Portland, with only three coming in the second half.