Angela Stanford shot a 5-under 67 on Friday to take a two-stroke lead over Inbee Park after the second round of the Lorena Ochoa Invitational.
The winner of the inaugural tournament in 2009, Stanford had an 11-under 133 total at Guadalajara Country Club. The Texan won the HSBC Women's Champions in Singapore in February for her fifth LPGA Tour victory.
Park, from South Korea, had a 68.
Cristie Kerr was third at 8 under after a 69.
Second-ranked Stacy Lewis, coming off her tour-leading fourth victory of the season Sunday in Japan, was 7 under along with So Yeon Ryu and Candie Kung. Lewis and Ryu shot 70, and Kung had a 71.
Lewis has a 58-point lead over Park with two events left in the player of the year points race, putting her in position to become the first American to win the award since Beth Daniel in 1994.
Michelle Wie, tied for the first-round lead with Stanford and Kung after a 66, had a 75 to drop into a tie for 12th at 3 under. Wie won the 2009 tournament.
Top-ranked Yani Tseng also was 3 under after a 71.
Ochoa was 1 under after a 72. The Mexican star won 27 LPGA Tour titles before retiring at age 28 in 2010. She missed the event last year before the birth of son Pedro in December.
Suzann Pettersen, coming off consecutive victories in South Korea and Taiwan, was even par after a 74.