Paceman Peter Siddle struck in the first ball of his first over to remove Sehwag caught and bowled for 18 after the opener got the bottom of his bat onto a full toss.
Dravid was bowled for the sixth time in seven innings in the series in the next over, deceived by a Ben Hilfenhaus delivery that struck the Indian on his elbow and hit the stumps.
Already 3-0 down in the series after three emphatic defeats, India had laboured in the field as Clarke and Ponting ruthlessly, and often stylishly, drove home their advantage.
Resuming at 335-3, they passed their own record partnership for Australia against India of 288, which they set in the Sydney test, inside the first hour.
In Image: Australia's Peter Siddle celebrates his dismissal of Indian's Batsman Virender Sehwag