The win was a stunning turnaround from the third test in Perth, where England slumped to a 267-run defeat that levelled the series 1-1.
Australia's resurgence on the fast WACA wicket proved little more than a mirage when their batsmen, brittle throughout the series, were skittled for a first innings total of 98, a record low against the tourists at the MCG.
England pressed the advantage by romping to 157 for no loss on the first day and anchored by a sublime unbeaten century by Jonathan Trott, who was named man of the match, posted a first innings total of 513 on day three.
That gave the hosts a 415-run deficit to make England bat again and any hope of a fightback was quashed after tea when Australia's top order were blown away by Bresnan.
Image: England's captain Andrew Strauss, right, shakes hands with Australia's captain Ricky Ponting at the end of the fourth Ashes cricket test against Australia at the MCG in Melbourne, Wednesday, Dec. 29, 2010.