Federer's unlikely 3-6 6-7 6-4 6-4 6-4 capitulation on a stunned Centre Court was the first time he had lost a grand slam match from two sets up and meant there would be no repeat of the repeat of the semi-final line-up at the French Open in which the world's leading quartet faced off.
The other usual suspects will be present although defending champion Rafa Nadal had painkilling jabs to numb the pain of a mystery foot injury before a 6-3 6-3 5-7 6-4 defeat of American Mardy Fish to set up a repeat of last year's semi-final against Briton Andy Murray.
Fourth seed Murray, who also lost to Nadal in the French Open semis this month, outclassed unseeded Spaniard Feliciano Lopez 6-3 6-4 6-4 to the delight of the Centre Court crowd dreaming of a first British men's singles winner for 75 years.
Image: France's Jo-Wilfried Tsonga celebrates after defeating Switzerland's Roger Federer in their match at the All England Lawn Tennis Championships at Wimbledon, Wednesday, June 29, 2011.
Text: Reuters
Images: AP