The Guyana bowlers, lacking in international exposure, failed to make any impact against the top class RCB batsmen who scored runs almost at will.
With a meagre total of 104 to chase, Kallis and Dravid did not take much risk with too many shots before Uthappa ended the match in a flash by taking 21 runs in the 12th over with the help of two sixes and a four off Christopher Barnwell.
Uthappa hit the winning runs -- a four -- in the 13th over to overhaul the target.
Image: Royal Challengers Bangalore's batsman Robin Uthappa in action during the fourth match of the Champions League Twenty20 against Guyana at Super Sports Park in Centurion
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