Kayla McBride scored 19 points to help No. 2 Notre Dame beat Pittsburgh 73-47 on Wednesday night for the Irish's 12th-straight win.
Jewell Loyd added 14 points while Skylar Diggins had 13 — all in the first half.
With the game tied at 29, Notre Dame scored the final six points before break. The Irish continued the spurt in the second half, scoring 25 of the first 28 points.
Notre Dame (17-1, 6-0 Big East) led 60-32 with 10 minutes left and coasted from there. The Irish have won their last 11 Big East regular season road games, their best streak since joining the conference 18 seasons ago.
Brianna Kiesel scored eight points to lead Pitt (9-9, 0-5). The Panthers haven't won a Big East game since Feb. 15, 2011.
It was the first meeting between the two teams since Notre Dame dealt Pittsburgh its worst loss in program history, a 120-44 defeat on Jan. 17, 2012.
Trailing 16-5, the Panthers went on a 7-0 run to cut the lead to four with 12:38 remaining in the first half. Notre Dame went back ahead by eight on a layup by Pittsburgh native Madison Cable and another layup by Loyd, but the Panthers answered back with a 9-2 run and McGraw called timeout with her team ahead just 22-21 with 8:43 remaining.
Coming out of the timeout, Marquel Davis hit a layup and Cora McManus a 3-pointer to give Pittsburgh its first lead of the game, 25-22.
Diggins' 3-pointer tied the score and the Panthers missed their next six shots as Notre Dame went back ahead by four. Pittsburgh would tie it once more at 29 with 3:07 remaining in the half before Notre Dame closed with its 6-0 run.