Doug McDermott scored 27 points, Gregory Echenique had 12 points and 12 rebounds, and No. 16 Creighton pulled away in the second half for a 64-42 victory over Nebraska in the annual meeting of the state rivals Thursday night.
Creighton (8-1) won in Lincoln for the first time since 2004.
Dylan Talley scored 14 points and Brandon Ubel had eight points and 10 rebounds to lead the Cornhuskers (6-2).
Grant Gibbs had 10 assists for Creighton.
Creighton and Nebraska were meeting for the 46th time, and the home team had won the last seven games. The Huskers lead the series 25-21.
The crowd of 13,368 was the first sellout at the Devaney Center since the 2011 game against Kansas and first for a nonconference game since Creighton visited in 2006.
The Bluejays were without Josh Jones, their first man off the bench. Coach Greg McDermott was expected to address the reason for Jones' absence after the game. Jones averages 7.0 points and almost 20 minutes a game.
The Huskers came into the game off their best start since 2008-09 and double-digit wins over Wake Forest and Southern California.
Nebraska coach Tim Miles said Creighton would be the opponent his team would need to get a true measure of itself.
The Huskers drew the more talented Bluejays into a sacrifice-the-body type of game.
No play illustrated it better than when Nebraska's Mike Peltz, a walk-on guard from Alliance, went to the floor near midcourt to fight for a loose ball with Avery Dingman and Gibbs in what looked like a rugby scrum.
Nebraska fans, undoubtedly envious of the basketball success of the 6,000-student Jesuit school 50 miles away in Omaha, cheered any and all achievements of their Huskers, whether it was winning a loose ball or making a layup.
They howled when Miles drew a technical for protesting a no-call on what he and most folks in the building thought was traveling as McDermott scored inside. McDermott made the two free throws for a 15-point lead.
The Bluejays used a 13-5 run to pull away in the second half and led by as many as 22 points. Fans began leaving with 6 minutes to play.
Nebraska's Andre Almeida blocked the first shot of the game, by Echenique, in what was a symbolic start to a sloppy first half in which the Huskers shot 25 percent and the Bluejays 37 percent.
Almeida blocked two more shots and Shavon Shields another in the half. McDermott, who had one swatted by Almeida, found the going tough inside and missed six of his first eight shots.
The Huskers couldn't capitalize. They went more than 6 minutes between field goals during one stretch, putting up an air ball and a couple other shots that barely hit iron.
Echenique broke things open with consecutive dunks, the first on Gibbs' pass out of a trap and the second off Gibbs' mini alley-oop pass for a 21-12 lead.
Another big dunk to start the second half put Creighton up 30-17.