Brittney Griner scored the game's first five points and finished with 23 as Baylor led throughout in its first game since taking back the No. 1 spot, defeating 25th-ranked Iowa State 67-39 on Wednesday night.
Griner already had 11 points as Baylor (13-1, 3-0 Big 12) jumped out to a 16-3 lead in just over 8 minutes.
The Lady Bears set a Big 12 record with their 25th consecutive conference victory, breaking a tie with Oklahoma (24 in a row from March 2005-January 2007). Baylor has won 48 games in a row overall at home, the longest active winning streak.
Nikki Moody had 11 points for Iowa State (11-2, 2-1), which had won its first two Big 12 games for the first time in eight seasons, had 15 of its 24 turnovers by halftime.
In the final minute of the first half, Odyssey Sims stole the ball from Moody, who with a foul knocked Baylor's preseason All-American point guard to the ground.
Sims had made all 27 of her free throws this season — and 38 in a row going back to last season — before missing the front end of the bonus. But she almost immediately stole the ball from Chelsea Poppins and drove for a layup and a 35-19 halftime lead.
Iowa State made its first three shots of the second half, including a pair of 3-pointers by Moody. But the Cyclones were only within 42-27 when Nicole Blaskowsky made a jumper with her foot on the 3-point line, and Baylor then scored 17 consecutive points over the next 9 minutes.
Six different players scored for Baylor in that run, led by Destiny Williams' six points. Griner, the 6-foot-8 two-time All-American, had only one field goal in that spurt.
The Cyclones had held their first 12 opponents to only 48 points a game and allowed them to shot only 30 percent.
None of those were like Baylor.
The Lady Bears have won their Big 12 games this season by an average margin of 33 points, though this was the closest. They won by 39 points over TCU before beating then-No. 13 Oklahoma State by 34.
Griner made 10 of 20 shots with four rebounds and three blocked shots. Williams, Brooklyn Pope and Kimetria Hayden had 10 points each.
Sims finished with seven points after shooting 3-of-8 from the field and 1-of-4 from the free throw line, but she had six assists, four steals, four rebounds and only one turnover in her 32 minutes.
After Griner made two inside baskets, plus a free throw after being fouled on the second, in the first 1:22 of the game, Moody hit a 3-pointer for a 5-3 score.
The Cyclones then missed six shots in a row and had four turnovers before finally scoring again 7 minutes later, when a jumper by Moody made it 16-5 midway through the first half.
Pope's putback of a miss by Griner with 5:51 left in the first half put the Lady Bears up 26-11.
Pope then reached around Moody for a steal, and then got the ball back from Sims for a breakaway layup. Griner, who then had four points more than Iowa State's entire team, stood back at her offensive end and watched with both her arms thrust in the air.