The second experienced Australian batsman to call it a day after Ricky Ponting retired at the end of the 1-0 series defeat to South Africa in early December, Hussey leaves quite a gap in the middle order.
An ever-present in the team since he made his debut at the age of 30 in 2005, Hussey scored 6,235 runs at an average of 51.52 in 79 tests with 19 centuries.
Hussey was certain he would not be missed too much with his brother David - a limited overs international - among those in the frame to replace him.
"I am not worried about the team at all," he said. "History shows that the game always moves on, players come and go but the team will always move forward.
"I am really excited for... the team, because I think there are some brilliant candidates to come in and the emotional one would be Dave to come in.
"He's wanted to do it for a while and that would be amazing. But there are probably half a dozen very good candidates that I think can come in and do a fantastic job."
In Image: Australia's Michael Hussey is carried by Mitchell Johnson, left, and Peter Siddle, right, after Australia won their third cricket test match against Sri Lanka