The fifth seed, who had won the Thailand Open last week, defeated Li 13-21 22-20 21-19 in an hour and four minutes to lift her third title of the year.
"It was a really, really tough and I love the crowd here. It's really nice here. Whenever I enter the court, I feel like a champion here," said the world number five 22-year-old, who has earlier clinched the title in 2009 and 2010.
It was a battle of attrition for Saina against an opponent to whom she had lost four times and won just once -- that too way back in 2010 -- previously.
Image: India's Saina Nehwal waves her national flag after defeating China's Li Xuerui during their women's singles final match at Djarum Indonesia Open badminton tournament at Istora stadium in Jakarta, Indonesia, Sunday, June 17, 2012.