The crowd at Indore's Holkar Cricket Stadium witnessed two milestones as Sehwag's breath-taking 149-ball knock, studded with seven sixes and 25 fours, powered India to a massive 418 for five wickets, their highest ever ODI total.
In reply, West Indies simply caved in under the run mountain and barring Denesh Ramdin (96), none of their batsmen could provide substantial resistance as the visitors folded for 265 with four balls to go.
Ravindra Jadeja (3-34) was the pick of the Indian bowlers but debutant leg-spinner Rahul Sharma (3-43) impressed too.
Chennai hosts the fifth and final one-dayer on Sunday.
In Image: West Indies' player Marlon Samuels, left, congratulates India's captain Virender Sehwag, center, as he leaves the ground after losing his wicket
Text: Reuters
Images: AP