A 24th minute strike and then a 80th minute penalty from Forlan along with a last-minute header from Alvaro Pereira left Uruguay in a strong position on four points from two games while South Africa have just a point.
Group A rivals France and Mexico, who both drew their opening games face each other on Thursday in Polokwane.
Image:Diego Forlan kicks past Siboniso Gaxa and scores the opening goal
Text: Reuters
Images: AP