QPR boss Harry Redknapp described the 4-2 defeat by third-tier Milton Keynes Dons as "disgusting" but he retained only two players from the side that drew with West Ham United the weekend before.
Perhaps making a point to the club's powerbrokers about the paucity of his squad, Redknapp clearly chose to prioritise their fight to avoid relegation.
Norwich's elimination was less excusable. The Canaries enjoy the relative comfort of a seven-point cushion over the bottom three but still made six changes against Luton Town before becoming the first top-flight side in 24 years to lose to a minor league club.
The reality of the modern English game is the Premier League and Champions League are financial behemoths and clubs are less interested in silverware than keeping their noses in the money trough.
If top-flight survival is threatened or there is even an outside chance of reaching the promised land of a top-four place and Champions League qualification, then the FA Cup takes a back seat.
Liverpool reached the FA Cup final and won its poorer sibling, the League Cup, last season but still sacked manager Kenny Dalglish after their stumbling league form ended in an eighth-place finish.
Dalglish was later quoted as saying that not even an FA Cup victory would have kept him in his job.
It was perhaps with those words ringing in his ears that Liverpool manager Brendan Rodgers made five changes to his side at third-tier Oldham Athletic on Sunday including dropping captain Steven Gerrard to the bench.
Liverpool were roughed up 3-2 by Oldham in a defeat that hinted at the fact that cultured Premier League sides had forgotten how to deal with the old-fashioned high ball into the box, part of the staple diet of lower division clubs.
Rodgers then chose to point the finger at those he had drafted in.
"I was disappointed with the young players. We're trying to give them experience and let them see what it's like to play for Liverpool," he told reporters.
Liverpool are seventh in the league but it seems the outside chance they have of finishing in the top four made changes inevitable.
It is unlikely that 22-year-old centre back Sebastian Coates or 19-year-old full back Jack Robinson will be retained when Liverpool get back to league business against Arsenal on Wednesday.
The seven-times FA Cup winners were not alone in concentrating on their Champions League potential.
Tottenham made five alterations for a 2-1 defeat at second-tier Leeds United while Chelsea also changed five players as they twice came from behind to draw 2-2 at third-tier Brentford.
Former Liverpool defender Mark Lawrenson said the world's oldest knockout competition was now just a shop window for players on the fringes of squads, an opportunity for individualism to replace the team ethic embraced by lower league giant-killers.
The former Ireland international also suggested the FA Cup had lost its lustre for players used to Premier League luxury.
"What a sad sign of the times it is that the wages in the Premier League are so fantastic that for many players top-flight football is the be-all and end-all," he wrote in the Daily Mirror.
"The brutal truth is the FA Cup for some players has gone down the scale in terms of competitions they want to do well in."
A drastic solution such as giving the winners one of the four Champions League places would undoubtedly encourage teams to place more emphasis on the competition in the future.