England required nine further wickets to take a 1-0 lead in the four-match series against world number one side India at the close of the penultimate day of the first test at Lord's on Sunday.
After wicketkeeper Matt Prior had completed his sixth test century India, set 458 to win, were 80 for one with a maximum 98 overs to be bowled on Monday's final day.
Prior (103 not out) and Stuart Broad (74 not out) added 162 for the seventh wicket before Andrew Strauss declared his team's innings closed for the second time in the match on 269 for six.
Scorecard | India vs England
The highest total to win at Lord's remains the 344 for one scored by West Indies in 1984 while the biggest winning total anywhere is West Indies 418 for seven against Australia in 2003.
England, who have won four of their last 10 series at Lord's with six draws, can take over from India at the top of the world rankings if they win the series by at least a two-test margin.
India opened with first innings centurion Rahul Dravid in place of Gautam Gambhir, who left the field after he was hit painfully on the left arm at short-leg after a full-blooded sweep from Prior.
To add to their woes, Sachin Tendulkar, still one short of his 100th international century, has to wait until 258 minutes of the Indian innings has elapsed or the fifth wicket has fallen before he can bat as he was absent from the field for most of the day because of a virus infection. He still has to wait for around two hours 20 minutes on Monday.
Prior, who scored 71 in the first innings, demonstrated his value again at number seven.
His second 50 took only 42 balls, including a pulled six off Suresh Raina's occasional off-spin. Broad, who recorded his highest test score of 169 in last year's Lord's test against Pakistan, also played an innings of genuine quality with one dazzling off-drive to the boundary.
Gambhir rushed to hospital for X-ray after nasty hit
The pair scored at just under a run a ball although India were merely going through the motions in the latter stages of the partnership as they waited for the declaration.
Dhoni was reduced to bowling himself for the third time in the match, while Dravid donned the wicketkeeper's gloves and pads, in partnership with Raina to a widespread field.
Ishant Sharma, who conceded 128 runs without taking a wicket in England's first innings, rocked England in the morning session with three wickets in 16 balls to reduce the home side to 62 for five.
The loose-limbed paceman, his long black hair flopping in the sunlight, dismissed Kevin Pietersen (1), Ian Bell (0) and Jonathan Trott (22). He followed up with the wicket of Eoin Morgan (19) after the interval.
Dhoni in danger of one-match ban for slow over rate
Pietersen, England's first innings hero with an unbeaten 202, edged a steepling delivery to Mahendra Singh Dhoni behind the stumps. The same combination accounted for Bell in the same over, nibbling fatally outside the off stump.
Mysteriously Dhoni did not call on Sharma until 11 overs had been bowled after the lunch interval when he accounted for Morgan for 19, caught by Gautam Gambhir diving forward at mid-wicket after he failed to get hold of a pull shot.
Broad, who took four for 37 in India's first innings, struck with the third ball of his first over on Sunday evening, bowling Abhinav Mukund (12) for the second time in the match. On both occasions the batsman dragged the ball on to this stumps.
Dravid continued where he had left off in his undefeated 103 in the first innings to reach 34 not out with adroit footwork to negate any threat from England's only spinner Graeme Swann. Vangipurappu Laxman, who stroked Chris Tremlett for three successive boundaries, was on 32.