Sabine Lisicki ended Serena Williams' long winning streak, she ended her Grand Slam winning streak and she knocked the top seed, world No. 1 and defending champion out of Wimbledon on Super Monday.
Lisicki jumped on Williams early, survived an eight-game drought in the middle, then came back from a break down in the third set twice on her way to a 6-2, 1-6, 6-4 victory.
Williams had won 34 consecutive matches before running into the big-serving German, who matched Williams' power and exploited the American's nervous mistakes.
Lisicki reaches the semifinals at the All England Club for the second time and stamps herself as a favorite in the depleted women's draw.
Earlier, Britain's Laura Robson was beaten by Kaia Kanepi in the fourth round at Wimbledon, going down to the Estonian 7-6 (8-6) 7-5 on Court One.
Robson was bidding to become the first British woman to reach the quarter-finals at SW19 since Jo Durie in 1984.
However, Robson lost the first-set tie-break having been 5-2 ahead and was broken at 5-5 in the second.
Robson, 19, saved four match points as her rival started to creak on serve but Kanepi converted the fifth.
Image of Jana Novotna Jana Novotna Former Wimbledon champion and BBC Radio 5 live pundit
Robson was the first British woman to make the second week at Wimbledon since Sam Smith in 1998.