Sabine Lisicki ended Serena Williams' long winning streak, she ended her Grand Slam winning streak and she knocked the top seed, world No. 1 and defending champion out of Wimbledon on Super Monday.
Lisicki jumped on Williams early, survived an eight-game drought in the middle, then came back from a break down in the third set twice on her way to a 6-2, 1-6, 6-4 victory.
Williams had won 34 consecutive matches before running into the big-serving German, who matched Williams' power and exploited the American's nervous mistakes.
Lisicki reaches the semifinals at the All England Club for the second time and stamps herself as a favorite in the depleted women's draw.
Earlier, Britain's Laura Robson was beaten by Kaia Kanepi in the fourth round at Wimbledon, going down to the Estonian 7-6 (8-6) 7-5 on Court One.
Robson was bidding to become the first British woman to reach the quarter-finals at SW19 since Jo Durie in 1984.
However, Robson lost the first-set tie-break having been 5-2 ahead and was broken at 5-5 in the second.