Antonio Di Natale put Italy in front after an excellent setup from Andrea Pirlo in the 61st minute, but Cesc Fabregas tied it for the defending champions three minutes later by finishing off a dazzling display of Spain's trademark passing game.
Spain, which followed up its Euro 2008 victory with the 2010 World Cup title, dominated the Group C match for long stretches but struggled to finish at times, while Italy relied on dangerous counterattacks.
The draw ended a 14-match winning streak for Spain in competitive matches, which began after a 1-0 loss to Switzerland to open the last World Cup.
In Image: Spain's Andres Iniesta fails to score past Italy's Daniele De Rossi, left, and Italy goalkeeper Gianluigi Buffon, right, during the Euro 2012 soccer championship Group C match
Text and Images: AP