A win will ensure a Super Eights berth for champions of the 2007 edition even before they take on England in their second and final group league match on September 23.
In their only meeting till date, India had comfortably beaten Afghanistan by seven wickets during the last edition of World T20 in the West Indies.
While the battle of attrition will start once India take on England, a smooth start against the Afghans will certainly help the 'Men in Blue' hit a good rhythm and the team management will have an idea about the performance of their preferred combination.
The Indians are faced with the dilemma of whether to go in with five specialist bowlers or opt for the additional batsman, considering that bowling in the death overs has been a worry.
Skipper Mahendra Singh Dhoni is not someone who is known to tinker with the playing XI and believes in giving his preferred players a long rope. In fact, he has indicated that he would go in with four specialist bowlers and rely on his part-timers to fill in the fifth bowler's quota.
But if the part-timers do not perform upto expectation, he is willing to go in with five specialist bowlers.
The batting order looks more or less settled with seasoned opening pair of Gautam Gambhir and Virender Sehwag, solid middle-order consisting of Virat Kohli, Yuvraj Singh and Dhoni himself, it will be interesting to see what kind of bowling combination Dhoni-Fletcher pair use.
While pace spearhead Zaheer Khan and Irfan Pathan are two automatic selections, there is a strong case for seamer Lakshmipathy Balaji who has had some good performances in this format in the Indian Premier League. Balaji has a lot of variety and is an effective bowler at the death overs, though he went for runs in the warm-up game against Pakistan.
Of late, the nature of the 22-yard strip at the R Premadasa Stadium has undergone a change and the faster bowlers have been getting a lot of help.
Therefore, if India go onto play three seamers, it will again be a toss-up between in-form Ravichandran Ashwin and comeback man Harbhajan Singh.
Both played in the two practice games. While together they gave away only 37 runs in their eight overs with the senior off-spinner taking the wicket of Kumar Sangakkara in the first warm-up game, in the match against Pakistan, Harbhajan turned out to be expensive, giving away 40 runs from four overs.
Ashwin, however, continued his fine form with figures of four for 23.
As Ashwin has done well in recent times, the lanky Tamil Nadu lad is a front-runner in case India play four bowlers. The fifth bowler if need be can be anyone amongst Yuvraj Singh, Virender Sehwag, Suresh Raina and Rohit Sharma.
As far as batting is concerned both Sehwag and Gambhir didn't have a good time against New Zealand and an unfancied Afghanistan attack is just the stuff they need to find some form going their way.
Gambhir, who retired hurt during the warm-up match against Sri Lanka after being hit by a Lasith Malinga delivery, scored just 10 against Pakistan yesterday but the opener is now fit and would be keen to regain his form.
Sehwag, who had missed the last two World T20 editions due to injury, will look to make amends in a format where he hasn't performed up to expectations during international matches.
All eyes will be on India's 'man of the moment', Kohli who has been in stupendous form in all three formats.
Kohli, who has deservingly won the ICC's 'ODI Cricketer of the Year' award, will like to showcase his wide range of strokes in the shortest format.
India's performance will also depend on how well Kohli performs at the crucial no 3 position as he has, of late, been the architect of most of the team's ODI victories.
He will certainly like to replicate that show in the shortest format especially after his dismissal after a good knock was one of the primary reason for India's one-run loss against New Zealand in the T20 International in Chennai.
Yuvraj, who gave an impressive account during his comeback match after surviving a rare germ-cell cancer, will be keen on winning a few matches on his own just like he made the difference in the inaugural edition of the tournament, especially against England and Australia.
Skipper Dhoni has been one of India's premier limited overs player and one would expect that he doesn't keep it for too late as he did and paid the price against New Zealand.
However, Dhoni provided glimpses of his destructive ability during his innings of 55 off 42 balls during warm-up game against Sri Lanka.
Suresh Raina is also a destructive player in this format, while Rohit Sharma, who returned to form with a 40-ball 56 against Pakistan in the second warm-up match, will be happy to continue the momentum after a horrible series against Sri Lanka.
Manoj Tiwary, who has done pretty well in limited chances he has got so far, is an option if team management decides to bench any of the middle-order batsman.
India: Mahendra Singh Dhoni (Capt.), Gautam Gambhir, Virender Sehwag, Virat Kohli, Yuvraj Singh, Suresh Raina, Rohit Sharma, Manoj Tiwary, Irfan Pathan, Ravichandran Ashwin, Harbhajan Singh, Zaheer Khan, Ashok Dinda, L Balaji, Piyush Chawla.
Afghanistan: Nawroz Mangal (Capt.), Asghar Stanikzai, Dawlat Zadran, Gulbodin Naib, Hamid Hassan, Izatullah Dawlatzai, Javed Ahmadi, Karim Sadiq, Mohammad Nabi, Mohammad Shahzad, Najibullah Zadran, Mohammad Nasim Baras, Samiullah Shenwari, Shafiqullah, Shapoor Zadran.