Red Bull's 26-year-old German was fastest in both sessions, with Australian Mark Webber the closest to matching his team mate.
Despite Vettel's speed, it was not all smooth running for the champion who had a problem with the KERS energy recovery system and complained about the soft tyres degrading too quickly.
"The tyre has too much energy, just gives up. Same for everybody," he told reporters. "Sunday it could be a short stint on the option tyre but usually the track rubbers in and things improve."
In Image: Red Bull driver Sebastian Vettel of Germany waits in his car during the second practice session at the Indian Formula One Grand Prix at the Buddh International Circuit in Noida, India, Friday, Oct. 25, 2013