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Gene variant in East Asians could explain resistance to cancer drugs
Scientists have now found answer to why some patients fail to respond to some of the most successful cancer drugs. Tyrosine kinase inhibitor drugs (TKIs) work effectively in most patients to fight certain blood cell cancers, such as chronic myelogenous leukemia (CML), and non-small-cell lung cancers (NSCLC) with mutations in the EGFR gene. These precisely targeted drugs shut down molecular pathways